Author, publication year, (Ref.)	Participants		Statin			Mean LDL-C reduction (%)	Method	Main results
Author, publication year, (Ref.)	At baseline	At follow-up	Type	Dose (mg)	Duration
Wiegman, 2004 (20)	FH with statins (n = 106, 13 ± 3.0 yrs), FH with placebo (n = 108, 13 ± 2.9 yrs)	FH with statins (n = 104, 15 ± 3.0 yrs), FH with placebo (n = 107, 15 ± 2.9 yrs)	pravastatin	20-40	2 yrs	24.1	carotid IMT	Regression of IMT in adolescents after 2 years of pravastatin compared to those who got placebo.
Hedman, 2005 (32)	FH (n = 30, 10.1 ± 3.4 yrs)	FH (n = 30)	pravastatin	Oct-60	1 – 2 yrs	33.1	carotid IMT	Non-significant increase in the IMT after 1 and 2 years of pravastatin.
van der Graaf, 2006 (23)	FH (n = 84, 12.6 ± 2.1 yrs)	FH (n = 84, 14.6 ± 2.1 yrs)	fluvastatin	80	2 yrs	33.9	carotid IMT	No differences in IMT after 2 years of fluvastatin therapy.
Rodenburg, 2007 (30)	FH (n = 186, 13.7 ± 3.1 yrs)	FH (n = 186, 18.2 ± 2.6 yrs)	pravastatin	20-40	2 yrs	29.2	carotid IMT	Regression of IMT in adolescents after early initiation of pravastatin.
Kusters, 2014 (14)	FH (n = 194, 12.9 ± 0.5 yrs), unaffected sibling (n = 83, 13.0 ± 0.7 yrs)	FH (n = 19.4, 24.0 ± 0.5 yrs), unaffected siblings (n – 83, 23.8 ± 0.7 yrs)	pravastatin	20-40	10 yrs	27.1	carotid IMT	Increased IMT in FH compared to unaffected siblings at baseline. Same progression of IMT after 10 years of Pravastatin, but still significantly greater IMT.
Kusters, 2014 (14)			pravastatin	20-40	10 yrs	27.1	carotid IMT
Braamskamp, 2017 (31)	FH (n = 198, 12.1 ± 3.3 yrs), unaffected siblings (n = 65, 12.0 ± 3.5 yrs)	FH (n = 197), unaffected siblings (n = 65)	rosuvastatin	Oct-20	2 yrs	41	carotid IMT	Increased IMT in FH compared to unaffected siblings at baseline. Less progression of IMT in children with FH after 2 yrs Rosuvastatin.
Braamskamp, 2017 (31)		FH (n = 197), unaffected siblings (n = 65)	rosuvastatin	Oct-20	2 yrs	41	carotid IMT
Luirink, 2019 (29)	FH (n = 214, 13.0 ± 2.9 yrs), unaffected siblings (n = 95, 12.9 ± 2.9)	FH (n = 184, 31.7 ± 3.2 yrs), unaffected siblings (n = 77, 31.6 ± 3.0 yrs)	pravastatin	20-40	20 yrs	32	carotid IMT	Increased IMT in FH compared to unaffected siblings at baseline. Slowed progression of IMT after 20 years of Pravastatin.
			simvastatin	20-80
			atorvastatin	Oct-80
			rosuvastatin	May-40
Hennig, 2020 (28)	FH (n = 57, 9.57 ± 3.26 yrs)	FH with diet only (n = 12), FH with statin (n = 20)	rosuvastatin	May-40	1 yr	34.4	Carotid IMT	Insignificant decrease in the IMT after 1 year of statin treatment.